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Korean J Gastroenterol  <  Volume 37(2); 2001 <  Articles

Korean J Gastroenterol 2001; 37(2): 98-105  
간 / B형 간염 바이러스 Core 유전자의 변이가 급성 B형 간염의 중증도에 미치는 영향
김연수(Yun Soo Kim),김영석(Young Seok Kim),차상우(Sang Woo Cha),문종호(Jong Ho Moon),조영덕(Young Deok Cho),이문성(Moon Sung Lee),변관수(Kwan Soo Byun),심찬섭(Chan Sup Shim),서동진(Dong Jin Suh),이창홍(Chang Hong Lee)
Published online: February 25, 2001.
© The Korean Journal of Gastroenterology. All rights reserved.

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background/Aims: Missense mutation of hepatitis B virus (HBV) core gene has been reported to be frequent in fulminant hepatitis (FH) B. This study was carried out to investigate whether there is a difference in severity of the disease according to the presence of the mutation in acute viral hepatitis (AVH) B. The codon sites with missense mutation were compared to those of chronic hepatitis (CH) B. Methods: HBV core gene sequences were analysed by PCR-direct sequencing method in 25 cases of AVH-B (23 self-limited AVH and 2 FH). Results: Missense mutation was observed in 7 cases of self-limited AVH and 2 cases of FH. In patients with self-limited AVH, the mean levels of serum ALT and total bilirubin were 1912±801/1140±521 IU/L (p<0.05) and 11.6±5.8/9.0±4.5 mg/dL (patients with the mutations/patients without mutations), respectively. Most frequent mutations observed in the cases of self-limited AVH were substitutions of Ile to Leu at codon 97 and Pro to Thr at codon 130, which had been reported to be frequent in the CHB. Conclusions: There was a tendency for the patients infected with the core mutant to suffer from severe hepatitis even in the self-limited cases. Common sites of missense mutation in AVH-B were same as those in CHB. (Korean J Gastroenterol 2001;37:98-105)
Keywords: Hepatitis B virus, Core mutation, Acute viral hepatitis B, Fulminant hepatitis, Severity of hepatitis, B형 간염 바이러스, 급성 B형 간염, 전격성 간염, core 변이, 간염의 중증도


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