Summary of Hypersensitivity Reactions Occurring in the Patient
Cycle | Situation at the time of symptom onset | Hypersensitivity reactions | Grade |
---|---|---|---|
19th cycle (failed) | 30 minutes after the start of oxaliplatin and leucovorin infusion | Facial flushing, pruritus on the trunk, hypotension, SpO2 89% | 4 |
19th cycle (retry) | 20 minutes after the initiation of leucovorin infusion | Facial flushing, dyspnea | 2 |
20th cycle | 5 minutes after the initiation of leucovorin infusion | Dyspnea, urticaria | 2 |
21st cycle | 20 minutes after the start of leucovorin infusion without the previous administration of oxaliplatin | Facial flushing | 2 |
22nd cycle | 30 minutes after the start of leucovorin infusion | Redness on the trunk, dyspnea | 2 |
23rd cycle | 15 minutes after the start of leucovorin infusion in a 1:100 diluted dose | Facial flushing, dyspnea | 4 |
SpO2, peripheral capillary oxygen saturation.