The Korean Journal of Gastroenterology :eISSN 2233-6869 / pISSN 1598-9992


Table. 2.

Adverse Effects of Therapeutic Agents for Autoimmune Hepatitis

Agent Adverse effects Notes
Predni(so)lone Cushingoid features, weight gain, osteoporosis, brittle diabetes, cataract, psychosis, hypertension Adverse effects related to the high initial doses
Mostly resolved by rapid tapering; or to maintenance dose exceeding 10 mg/day
Azatioprine Nausea, heartburn, hepatotoxicity, hair loss, loss of appetite, fatigue, unusual bruising, myelosuppression, decreased resistance to infection, possibly increased risk of developing cancer Mostly well tolerated
Not tolerated with skewed metabolism from genetic polymorphism
Mycophenolate mofetil Nausea, vomiting, diarrhea, heartburn, headache, dizziness, skin rash, decreased resistance to infection, myelotoxicity, teratogenicity More effective second-line therapy in patients intolerant than unresponsive to azathioprine
Contraindication in pregnancy
Cyclosporin, Tacrolimus Nephrotoxicity, hepatotoxicity, decreased resistance to infection, hypertension, hyperlipidemia, hyperkalemia, hyperuricemia, hypomagnesemia, glucose intolerance, tremors, lymphoma, hirsutism (cyclosporin), gum hypertrophy (cyclosporin), alopecia (tacrolimus) Adverse effects related to the dose/blood levels
Necessity to monitor blood levels
Korean J Gastroenterol 2023;81:72~85
© Korean J Gastroenterol