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Table. 2.

TTE Parameters in NAFL versus NASH Patients, Advanced-stage versus Non-advanced Stage NAFLD Patients, and High-grade versus Lower-grade NAFLD Patients

TTE Parameters NAFL (n=17) NASH (n=16) p-value Non-advanced NAFLDa (n=26) Advanced Stage NAFLDb (n=7) p-value Lower-grade NAFLDc (n=22) High-grade NAFLDd (n=11) p-value
E/e’ 8.8±2.0 11.8±3.3 0.004 9.7±3.0 12.4±2.7 0.021 9.3±2.7 12.2±2.9 0.00
E/A 1.2±0.5 1.1±0.4 0.533 1.2±0.4 1.2±0.5 0.880 1.1±0.4 1.2±0.4 0.36
Diastolic dysfunction 1 (6.0) 5 (31.0) 0.051 3 (12.0) 3 (43.0) 0.077 2 (9.0) 4 (36.0) 0.06
LVEF (%) 62.0±8.0 64.0±6.0 0.309 63.0±7.0 64.0±7.0 0.747 63.0±8.0 63.0±7.0 0.90
LV Mass Index (by BSA, g/m2) 81.2±18.7 82.3±20.0 0.790 79.5±17.6 89.9±23.3 0.352 80.6±16.8 84.0±23.6 0.64
LA volume index (by BSA, mL/m3) 19.8±7.4 23.5±7.1 0.168 21.3±7.3 22.8±8.0 0.780 20.9±7.7 23.1±6.9 0.40
Average strain (%) -17.2±2.6 -18.3±3.5 0.345 -17.9±2.8 -17.3±4.3 0.503 -17.6±2.5 -18.1±4.1 0.87
TR velocity (cm/s) 2.2±0.6 (n=8) 2.4±0.3 (n=8) 0.721 2.2±0.5 (n=12) 2.6±0.3 (n=4) 0.379 2.2±0.3 (n=10) 2.5±0.3 (n=6) 0.37
Estimated PASP (mmHg) 25.6±7.8 (n=7) 26.0±12.3 (n=8) 0.779 25.7±6.2 (n=11) 26.0±18.6 (n=4) 0.661 25.4±6.9 (n=9) 26.3±14.5 (n=6) 0.53

Values are presented as mean±standard deviation or number (%).

TTE, transthoracic echocardiogram; NAFL, nonalcoholic fatty liver; NASH, nonalcoholic steatohepatitis; NAFLD, nonalcoholic fatty liver disease; LVEF, left ventricular ejection fraction; LV, left ventricular; LA, left atrial; BSA, body surface area; TR, tricuspid regurgitation; PASP, pulmonary artery systolic pressure.

aNon-advanced stage NAFLD=NASH Stage 1-2 + NAFL; bAdvanced-stage NAFLD=NASH Stage 3-4; cLower-grade NAFLD=NASH Grade 1 + NAFL; dHigher-grade NAFLD=NASH Grade 2-3.

Korean J Gastroenterol 2021;78:161~167 https://doi.org/10.4166/kjg.2021.040
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