The Korean Journal of Gastroenterology :eISSN 2233-6869 / pISSN 1598-9992

 

Table. 1.

Characteristics and Outcomes of Clinical Trials on Fecal Microbiota Transplantation for Ulcerative Colitis

Study DA N (FMT/control) Control intervention Donor Dosage Frequency Delivery F/U Remission
Moayyedi et al.26 (2015) [Mayo clinic score ≥4 with an endoscopic Mayo clinic score ≥1] 75 (38/37) Water enema Single 50 g stool in 300 mL water 6 (weekly) Enema 7 weeks FMT 24%, control 5%, p=0.03
Rossen et al.27 (2015) [SCCAI ≥4 and ≤11] 48 (23/25) Autologous fecal microbiota Single ≥60 g stool in 500 mL saline 2 (at week 0 and 3) Naso-duodenal 12 weeks FMT 30.4%, control 20.0%, p=0.51
Paramsothy et al.28 (2017) [Mayo score: 4-10] 81 (41/40) Saline enema Multi-donor 37.5 g stool in 150 mL saline 40 (1 colonoscopic infusion then enemas 5/week for 8 weeks) Colonoscopy→ enema 8 weeks FMT 27%, control 8%, p=0.021
Costello et al.29 (2019) [Total Mayo score 3-10 and an endoscopic subscore of ≥2] 73 (38/35) Autologous stool Multi-donor 50 g stool in 200 mL saline via colonoscopy +25 g stool in 100 mL saline via enema 3 (at week 0 colonoscopy, at week 1 two enemas) Colonoscopy→ enema 8 weeks FMT 32%, control 9%, p=0.02
Sood et al.30 (2019) [Mayo score 4-10] 61 (31/30) Saline+SOC Single 100 g stool in 200 mL saline 7 (at weeks 0, 8, 16, 24, 32, 40 and 48) Colonoscopy 48 weeks FMT+SOC 87.1%, control+SOC 66.7%, p=0.11
Sood et al.31 (2021) [Mayo clinic score ≥6 and Mayo endoscopic subscore ≥2] 93 patients (FMT group) None (no control group) Single 80 g stool in 200 mL saline 7 (at weeks 0, 2, 6, 10, 14, 18 and 22) Colonoscopy 30 weeks 61.29% in FMT group

DA, disease activity; SSCAI, simple clinical colitis activity index; SOC, standard of care (5-ASA with/without azathioprine).

Korean J Gastroenterol 2021;78:31~36 https://doi.org/10.4166/kjg.2021.089
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