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Table. 2.

Summary of the Evidence According to PICO; Does Eradication of Helicobacter pylori Prevent Ulcer and Bleeding in Patients on Long-term Low Dose Aspirin Therapy Who Have a History of Peptic Ulcer?

Reference Study design Participants Intervention and comparator Outcomes reported Primary outcome
Chan et al. (2001)27 RCT patients with a history of UGI bleeding who were infected with H. pylori and taking LDA H. pylori eradication (1-week course of triple therapy) vs. omeprazole 1.9% (eradication therapy) vs. 0.9% (omeprazole) the probability of recurrent bleeding during the six-month period

Reference Study design Participants Outcomes reported Primary outcome

Chan et al. (2013)28 Prospective cohort H pylori-positive LDA users with UGI bleeding in whom the infections were eradicated The incidence of ulcer bleeding (per 100 patient-years) in the H pylori-eradicated cohort (0.97; 95% CI, 0.53-1.80) did not differ significantly from that of the average-risk cohort (0.66; 95% CI, 0.38-0.99). the cumulative incidence of recurrent UGI bleeding with LDA use in 10 years.
H pylori-negative LDA users who developed bleeding ulcers
The average-risk cohort new users of LDA without a history of ulcers

PICO, population, intervention, comparison, outcome; RCT, randomized controlled trial; UGI, upper gastrointestinal; H. pylori, Helicobacter pylori; LDA, low dose aspirin; CI, confidence interval.

Korean J Gastroenterol 2020;76:227~231 https://doi.org/10.4166/kjg.2020.141
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