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Korean J Gastroenterol  <  Volume 75(4); 2020 <  Articles

Korean J Gastroenterol 2020; 75(4): 207-211  https://doi.org/10.4166/kjg.2020.75.4.207
A Collision Tumor of the Esophagus: Mixed Squamous Cell Carcinoma and Neuroendocrine Carcinoma
A Reum Choe, Ki-Nam Shim , Jiyoung Lim, Eun Mi Song, Chung Hyun Tae, Sung-Ae Jung and Min Sun Jo1
Departments of Internal Medicine and Pathology1, Ewha Womans University College of Medicine, Seoul, Korea
Correspondence to: Ki-Nam Shim, Department of Internal Medicine, Ewha Womans University College of Medicine, 25 Magokdong-ro 2-gil, Gangseo-gu, Seoul 07804, Korea. Tel: +82-2-6986-1622, Fax: +82-2-2650-2837, E-mail: shimkn@ewha.ac.kr, ORCID https://orcid.org/0000-0003-4004-6292
Received: January 3, 2020; Revised: January 28, 2020; Accepted: January 29, 2020; Published online: April 25, 2020.
© The Korean Journal of Gastroenterology. All rights reserved.

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Collision tumors are extremely rare, and currently, no therapeutic protocols are established. A 64-year-old man presented to his physician with complaints of right chest and abdominal pain. The contrast-enhanced CT scan showed a mass measuring 3.6 cm around the gastric fundus. Esophagogastroduodenoscopy was performed and a semicircular longitudinal ulcerative mass was found at the distal esophagus. A mass measuring about 4 cm with central ulceration was noted at the cardia. The esophageal biopsy revealed positivity for a component of neuroendocrine carcinoma adjacent to a squamous cell carcinoma. PET-CT revealed a mass in the esophagus and cardia and several tumors in the whole liver, pancreas, and bone. The patient was finally diagnosed with a collision tumor of the esophagus with multiple metastases. In conclusion, patients with collision tumors must undergo active multidisciplinary management that will include pathologists and oncologists, who will decide on proper treatment strategies.
Keywords: Esophageal neoplasms; Carcinoma; Neuroendocrine tumors

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