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Korean J Gastroenterol  <  Volume 75(3); 2020 <  Articles

Korean J Gastroenterol 2020; 75(3): 141-146  https://doi.org/10.4166/kjg.2020.75.3.141
Effects of Novel Probiotics in a Murine Model of Irritable Bowel Syndrome
Hye Gyo Chung, Yang Won Min , Chansu Lee, Sung Noh Hong, Ji Young Won1, Jin Ah Jang1, Cheol-Hyun Kim1 and Dong Kyung Chang
Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul; Department of Animal Resource & Science, Dankook University1, Cheonan, Korea
Correspondence to: Yang Won Min, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Korea. Tel: +82-2-3410-3409, Fax: +82-2-3410-6983, E-mail: yangwon.min@samsung.com, ORCID: https://orcid.org/0000-0001-7471-1305

Financial support: This work was supported by Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries (IPET) through High Value-Added Food Technology Development Program, funded by Ministry of Agriculture, Food and Rural Affairs (MAFRA) (316061-3).
Received: November 23, 2019; Revised: December 28, 2019; Accepted: January 8, 2020; Published online: March 25, 2020.
© The Korean Journal of Gastroenterology. All rights reserved.

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background/Aims: Dysbiosis is an important factor in the pathogenesis of irritable bowel syndrome (IBS). Several studies have reported promising results using probiotics for the treatment of IBS. This study evaluated the efficacy of novel probiotics isolated from Kimchi, a Korean fermented food, and the feces of healthy Vietnamese people in a murine model of IBS.
Methods: Lactobacillus paracasei DK121 was isolated from Kimchi, and L. salivarius V4 and L. plantarum V7 were isolated from the feces of healthy Vietnamese people residing in Korea. Forty rats were allocated to receive one of the study strains, a mixture of the strains, or the vehicle. After 5 days of administration, the rats were restrained in a cage to induce IBS. The effects of the probiotics on IBS were analyzed by evaluating the stool weights and stool consistency scores.
Results: The primary outcome was analyzed upon the completion of a three-week experiment. The rats in the V7 group showed lower stool weights than those in the control group at week 2 (median: 1.10 [V7] vs. 2.35 [control], p=0.04, Mann-Whitney U-test) and week 3 (median: 1.10 [V7] vs. 2.80 [control], p=0.017). The rats in the DK121 (median: 2.00, p=0.007), V7 (median: 2.00, p=0.004), and mixture (median: 1.50, p=0.001) groups showed better stool consistency scores at week 2 than the control group (median: 3.00).
Conclusions: The novel probiotics have beneficial effects on defecation in a murine model of IBS. Human studies confirming the efficacy are warranted.
Keywords: Probiotics; Irritable bowel syndrome; Defecation


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