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Korean J Gastroenterol  <  Volume 75(1); 2020 <  Articles

Korean J Gastroenterol 2020; 75(1): 39-45  https://doi.org/10.4166/kjg.2020.75.1.39
Effect of Sodium Cromoglycate on Acetic Acid-induced Ulcerative Colitis in Mice
Zahra Ghafouri, Saeid Seyyedian1, Jafar Nikbakht2, Ebrahim Kouhsari3,4, Sara Bayat1, Hamidreza Zargar5 and Gholamreza Houshmand6,7
Department of Biochemistry, Biophysics and Genetics, School of Medicine, Mazandaran University of Medical Sciences, Sari; Department of Internal Medicine, School of Medicine, Alimentary Tract Research Center, Ahvaz Jundishapur University of Medical Sciences1, Ahvaz; Department of Pharmacology, School of Medicine, Yasuj University of Medical Science2, Yasuj; Clinical Microbiology Research Center, Ilam University of Medical Sciences3, Ilam; Laboratory Sciences Research Center, Golestan University of Medical Sciences4, Gorgan; Department of Pharmacology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences5, Ahvaz; Department of Pharmacology, School of Medicine6, Gut and Liver Research Center7, Mazandaran University of Medical Sciences, Sari, Iran
Correspondence to: Gholamreza Houshmand, Department of Pharmacology, School of Medicine, Mazandaran University of Medical Sciences, Payambar Azam Complex, 18th km of Farah Abad Blvd, Khazar Square, Sari, Mazandaran, Iran. Tel: +98-914343838, Fax: +98-1133543081, E-mail: dr.houshmand_pharmaco@yahoo.com, ORCID: https://orcid.org/0000-0001-8931-9613

Financial support: Mazandaran University of Medical Sciences.
Received: June 26, 2019; Revised: November 10, 2019; Accepted: November 23, 2019; Published online: January 25, 2020.
© The Korean Journal of Gastroenterology. All rights reserved.

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background/Aims: Ulcerative colitis (UC) is a type of inflammatory bowel disease that mainly involves the colon. Thus far, glucocorticoids and amino-salicylate have been the main treatment.
Methods: To assess drugs with fewer side effects, this study evaluated the effects of sodium cromoglycate (SCG) on acetic acid-induced UC in rats. The treatment groups included SCG receivers (50 and 100 mg/kg, intra-orally) and sulfasalazine (SSZ) receivers (100 mg/kg, intra-orally). The colonic mucosal injury was assessed by clinical, macroscopic, and histopathological examinations.
Results: In the treatment groups with 50 and 100 mg/kg of SCG, the clinical activity score decreased to 2.67±0.18 and 1.73±0.21 (p<0.05), respectively, compared to the UC control group (3.21±0.31), and were higher than that of the group given the standard treatment of 100 mg/kg SSZ (1.10±0.09). The treatment groups with 50 and 100 mg/kg of SCG showed a lower clinical gross lesion score than the UC control group (2.91±0.28 and 2.10±0.43, vs. 4.49±0.61, p<0.05) and were higher than the standard group (0.95±0.18). Treatment with SCG (100 mg/kg) decreased the macroscopic scores significantly compared to the UC control group (p<0.05) on the 8th day.
Conclusions: SCG (100mg/kg) decreased significantly the clinical activity score, gross lesion, and percentage-affected area compared to the UC controls on the 8th day.
Keywords: Sodium cromoglycate; Acetic acid; Colitis, ulcerative


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