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Korean J Gastroenterol  <  Volume 75(1); 2020 <  Articles

Korean J Gastroenterol 2020; 75(1): 11-16  https://doi.org/10.4166/kjg.2020.75.1.11
Non-celiac Gluten Sensitivity
Ra Ri Cha and Hyun Jin Kim
Department of Internal Medicine, Gyeongsang National University Changwon Hospital, Gyeongsang National University College of Medicine, Changwon, Korea
Correspondence to: Hyun Jin Kim, Department of Internal Medicine, Gyeongsang National University Changwon Hospital, 11 Samjeongja-ro, Seongsan-gu, Changwon 51472, Korea. Tel: +82-55-214-3710, Fax: +82-55-214-3250, E-mail: imdrkim@naver.com, ORCID: https://orcid.org/0000-0003-3853-0229
Received: December 23, 2019; Revised: January 14, 2020; Accepted: January 14, 2020; Published online: January 25, 2020.
© The Korean Journal of Gastroenterology. All rights reserved.

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Non-celiac gluten sensitivity (NCGS) is a term that is used to describe individuals who are not affected by celiac disease or wheat allergy, yet they have intestinal and/or extra-intestinal symptoms related to gluten ingestion with improvement of their symptoms upon withdrawing gluten from their diet. Gluten-related disorder groups are manifested by symptoms of gastrointestinal tract disorders, as well as hematological dermatological endocrinological, gynecological, rheumatological and nervous system symptoms. It is believed that NCGS represents heterogeneous groups with different subgroups characterized by different etiologies, clinical histories and clinical courses. There also appears to be an overlap between NCGS and irritable bowel syndrome (IBS). There is a need for establishing strict criteria for diagnosing NCGS. The absence of validated biomarkers remains a significant limitation for research studies on NCGS. New evidence shows that a gluten-free diet may be beneficial for some patients with gastrointestinal symptoms, such as those symptoms commonly found in patients with IBS. Further studies about NCGS are needed.
Keywords: Nonceliac gluten sensitivity; Functional gastrointestinal disorders; Abdominal pain; Diarrhea; Glutens


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