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Korean J Gastroenterol  <  Volume 74(3); 2019 <  Articles

Korean J Gastroenterol 2019; 74(3): 130-136  https://doi.org/10.4166/kjg.2019.74.3.130
Hepatitis E Virus: Epidemiology, Diagnosis, and Management
Nae-Yun Heo
Division of Gastroenterology, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea
Correspondence to: Nae-Yun Heo, Division of Gastroenterology, Inje University Haeundae Paik Hospital, Inje University College of Medicine, 875 Haeun-daero, Haeundae-gu, Busan 48108, Korea. Tel: +82-51-797-2446, Fax: +82-51-797-1340, E-mail: nyheo@hanmail.net, ORCID: https://orcid.org/0000-0001-6571-8935
Received: August 12, 2019; Revised: August 27, 2019; Accepted: August 28, 2019; Published online: September 25, 2019.
© The Korean Journal of Gastroenterology. All rights reserved.

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
The HEV is a known cause of water-borne outbreaks of acute non-A non-B hepatitis in developing countries, which affects young people and may result in high mortality in pregnant women. In recent decades, however, HEV genotypes 3 and 4 have been known as a cause of sporadic zoonotic infections in older males from swine HEV worldwide. Most acute HEV infections are self-limited. On the other hand, in immunosuppressed patients, including solid organ transplant recipients, chronic HEV infections may exist and progress to liver cirrhosis or decompensation. Therefore, physicians need to recognize HEV as a major pathogen for acute and chronic hepatitis of unknown causes and investigate this disease.
Keywords: Hepatitis E; Waterborne diseases; Zoonoses; Genotype


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