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Korean J Gastroenterol  <  Volume 73(4); 2019 <  Articles

Korean J Gastroenterol 2019; 73(4): 225-229  https://doi.org/10.4166/kjg.2019.73.4.225
Recurrent Eosinophilic Pneumonia Associated with Mesalazine Suppository in a Patient with Ulcerative Colitis
Myoungrin Park, Junguee Lee1, Sang-Bum Kang2 and Yeonhee Park2
Department of Internal Medicine, VHS Daejeon Hospital; Departments of Pathology1 and Internal Medicine2, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Daejeon, Korea
Correspondence to: Yeonhee Park, Department of Internal Medicine, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 64 Daeheung-ro, Jung-gu, Daejeon 34943, Korea. Tel: +82-42-220-9589, Fax: +82-42-252-6807, E-mail: yhpark@catholic.ac.kr, ORCID: https://orcid.org/0000-0001-9537-1530
Received: October 23, 2018; Revised: December 11, 2018; Accepted: December 16, 2018; Published online: April 25, 2019.
© The Korean Journal of Gastroenterology. All rights reserved.

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Mesalazine suppositories are widely used to treat ulcerative colitis and have a guaranteed safety profile, but although rare, they can cause pulmonary toxicity. A 35-year-old woman with ulcerative colitis was diagnosed to have acute eosinophilic pneumonia after 29 days of oral mesalazine use and improved after mesalazine and corticosteroid were withdrawn. Reintroduction of mesalazine suppositories resulted in acute eosinophilic pneumonia recurrence after 28 days. Mesalazine re-administration (even via a different route) in patients with a history of mesalazine-induced eosinophilic pneumonia should be undertaken cautiously, because eosinophilic pneumonia may recurrence.
Keywords: Mesalazine; Mesalamine; Suppositories; Eosinophilic pneumonia; Pulmonary eosinophilia


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