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Korean J Gastroenterol  <  Volume 73(4); 2019 <  Articles

Korean J Gastroenterol 2019; 73(4): 202-206  https://doi.org/10.4166/kjg.2019.73.4.202
Systemic Therapy for Advanced and Metastatic Colon Cancer
Jae Jun Park
Division of Gastroenterology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
Correspondence to: Jae Jun Park, Division of Gastroenterology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea. Tel: +82-2-2228-5221, Fax: +82-2-393-6884, E-mail: jaejpark@yuhs.ac, ORCID: https://orcid.org/0000-0001-9974-1658
Received: February 18, 2019; Revised: March 25, 2019; Accepted: March 25, 2019; Published online: April 25, 2019.
© The Korean Journal of Gastroenterology. All rights reserved.

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Colon cancer is one of the three most common cancers in both men and women in Organization for Economic Cooperation and Development countries. Approximately one-quarter of colon cancer patients have a metastasis at the time of diagnosis, and systemic therapy is used in many of them as a first line therapy. In addition to existing cytotoxic drugs, target therapy has been introduced in colon cancer and immunotherapy has shown clinical benefits in the treatment of metastatic colon cancer. The purpose of this review was to briefly summarize the National Comprehensive Cancer Network guidelines for systemic therapy in colon cancer with special reference to targeted agents and novel agents.
Keywords: Colon cancer; Advanced cancer; Metastatic cancer; Systemic therapy


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