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Korean J Gastroenterol  <  Volume 67(6); 2016 <  Articles

Korean J Gastroenterol 2016; 67(6): 289-299  https://doi.org/10.4166/kjg.2016.67.6.289
Peptic Ulcer Disease Associated with Helicobacter pylori Infection
Se-Hwan Yeo and Chang-Hun Yang
Division of Gastroenterology & Hepatology, Department of Internal Medicine, Dongguk University School of Medicine, Gyeongju, Korea
Published online: June 25, 2016.
© The Korean Journal of Gastroenterology. All rights reserved.

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Although the global prevalence of peptic ulcer disease (PUD) is decreasing, PUD is still one of the most common upper gastro-intestinal diseases in the world due to Helicobacter pylori infection and increased use of non-steroidal anti-inflammatory drugs. In Korea, the prevalence of H. pylori infection is also declining, but it is still the major cause of PUD. The outcomes of H. pylori infection are caused by imbalances between bacterial virulence factors, host factors, and environmental influences. In this review, we describe the prevalence trends of H. pylori infection in Korea, the mechanism of H. pylori infection-related PUD, and treatment strategies. (Korean J Gastroenterol 2016;67:289-299)
Keywords: Helicobacter pylori; Peptic ulcer; Prevalence; Epidemiology; Therapy

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