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Table. 2.

The Studies of Relationship between Vitamin D Supplementation and Outcomes in IBD

References Country Study design, number of cases Intervention Outcome
Miheller et al. (2009)65 Hungary Prospective open label, 37 in inactive CD 0.5 μg alfacalcidiol (active vitamin D) daily or 1,000 IU cholecalciferol (plain vitamin D) daily for 12months Significanta reduction of CDAI score (69.4 to 57.0) and CRP level (15.8 to 7.8 mmol/L), and improvement of IBDQ score (51.0 to 44.4) at week 6 in alfacalcidiol group
Jørgensen et al. (2010)58 Denmark Randomized double-blind placebo-controlled, 94 in inactive CD 1,200 IU cholecalciferol daily for 12 months Reduction of relapse rate in cholecalciferol group (13% vs. 29% in placebo), but not insignificant (p=0.056)
Yang et al. (2013)61 USA Prospective open label, 18 in mild to moderate CD Initial 1,000 U cholecalciferol daily for 2 weeks and dose increase until above 40 ng/mL of 25[OH]D level or 5000 IU daily for total 24 weeks Significant reduction of CDAI score (230 to 118) and improvement of IBDQ score (156 to 180)
Garg et al. (2018)64 Australia Prospective pilot, 10 (5 in mild to moderate CD and 5 in mild to moderate UC) 5,000 or 10,000 IU cholecalciferol daily and dose adjustment every 4 weeks for target 25[OH]D level of 100-125 nmol/L for 12 weeks Significant reduction of HBI in CD, but not insignificant in SCCAI score in UC (p=0.051)
Jun et al. (2019)62 Korea Prospective, 70 (29 in CD and 41 in UC) 1,000 or 500 IU cholecalciferol daily for 6 months No significant difference of CRP between sufficient 25[OH]D level (>20 ng/mL) group and insufficient group in both CD and UC, and no significant change in partial Mayo score in UC

CD, Crohn’s disease; UC, ulcerative colitis; IBD, inflammatory bowel disease; HBI, Harvey Bradshaw index; CDAI, Crohn’s disease activity index; UCAI, ulcerative colitis activity index; CRP, C-reactive protein; IBDQ, IBD questionnaire; SCCAI, simple clinical colitis activity index.

aSignificant means less than 0.05 of p-value

Korean J Gastroenterol 2020;76:275~281 https://doi.org/10.4166/kjg.2020.160
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