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Table. 1.

The Studies of the Association between Vitamin D Status and Disease-related Outcomes in IBD

References Country Study design, number of cases Result
Joseph et al. (2009)66 India Cross-sectional, 34 in CD 25[OH]D level had negative correlation with HBI score in CD
El-Matary et al. (2011)46a UK Cross-sectional, 60 (39 in CD and 21 in UC) No correlation between 25[OH]D level and pediatric CDAIscore in CD or pediatric UCAI score in UC
Ulitsky et al. (2011)10 USA Retrospective cohort, 504 (403 in CD and 101 in UC) 25[OH]D deficiency (<20 ng/mL) had increased HBI score and decreased SIBDQ score in CD, but not UCAI score and SIBDQ score in UC
Hassan et al. (2013)47 Iran Cross-sectional, 60 (26 in CD, 34 in UC) No association between 25[OH]D deficiency (≤10 ng/mL)and CDAI score in CD or Truelove index score in UC, but significant association with IBD-related intestinal surgery
Garg et al. (2013)67 Australia Prospective, 71 (40 in CD and 31 in UC) Inverse correlation between 25[OH]D level and fecalcalprotectin in both CD and UC
Ananthakrishnan et al. (2013)43 USA Multi-institutional cohort, 3,217 (1,769 in CD, 1,448 in UC) 25[OH]D deficiency (<20 ng/mL) had increased risk of IBD-related surgery and hospitalization in both CD and UC
Ananthakrishnan et al. (2014)45 USA Multi-institutional cohort, 2,809 (1,565 in CD and 1,244 in UC) 25[OH]D deficiency (<20 ng/mL) had increased risk of any cancer and increase of 25[OH]D level had reduction in risk of colorectal cancer in IBD
Zator et al. (2014)63 USA Retrospective cohort, 101 (74 CD and 27 in UC) 25[OH]D insufficiency (<30 ng/mL) had earlier cessationof anti-TNF-α therapy in CD, but not in UC
Kabbani et al. (2016)44 USA Prospective longitudinal cohort, 965 (597 in CD,368 in UC) Low 25[OH]D level (<30 ng/mL) had increased HBI score in CD or UCAI score in UC and decreased SIBDQ score in UC
Alrefai et al. (2017)68 Canada Retrospective cohort, 201 in CD 25[OH]D deficiency (<30 nmol/L) had higher CRP level in CD
Jun et al. (2019)62 Korea Prospective, 266 (88 in CD and 178 in UC) Inverse correlation between 25[OH]D level and CRP levelin CD, but not in UC

CD, Crohn’s disease; UC, ulcerative colitis; IBD, inflammatory bowel disease; HBI, Harvey Bradshaw index; CDAI, Crohn’s disease activity index; UCAI, ulcerative colitis activity index; CRP, C-reactive protein; SIBDQ, short IBD questionnaire.

aPediatric study.

Korean J Gastroenterol 2020;76:275~281 https://doi.org/10.4166/kjg.2020.160
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